H2N2V1, 1968, Analysis, bibRecord, 000173

Nucleotide sequence analysis of the nucleoprotein gene of an avian and a human influenza virus strain identifies two classes of nucleoproteins

Identifieur interne : 000173 ( 1968/Analysis ); précédent : 000172; suivant : 000174

Nucleotide sequence analysis of the nucleoprotein gene of an avian and a human influenza virus strain identifies two classes of nucleoproteins

Auteurs : Alicia J. Buckler-White [États-Unis] ; Brian R. Murphy [États-Unis]

Source :

Virology [ 0042-6822 ] ; 1986.

RBID : ISTEX:98084CB03211A541DBD134D38B4116CA43D50FDB

Descripteurs français

English descriptors

KwdEn :
- Amino Acid Sequence, Base Sequence, Biological Evolution, Genes, Viral, Influenza A virus (genetics), Nucleoproteins (classification), Nucleoproteins (genetics), RNA, Viral (genetics), Sequence Homology, Nucleic Acid, Viral Proteins (classification), Viral Proteins (genetics).
MESH :
- chemical , classification : Nucleoproteins, Viral Proteins.
- genetics : Influenza A virus, Nucleoproteins, RNA, Viral, Viral Proteins.
Teeft :
- Amino, Amino Acid Sequence, Amino acid change, Amino acid homology, Amino acid sequence, Amino acid sequences, Amino acid substitutions, Amino acids, Avian, Avian influenza, Avian influenza virus, Avian influenza viruses, Avian strains, Base Sequence, Biological Evolution, Brownlee, Coding region, Evolutionary pathway, Gene, Gene sequences, Genes, Viral, Homology, Host range restriction, Human classes, Human influenza, Human influenza virus, Human influenza viruses, Human strains, Human viruses, Influenza, Influenza virus, Linear pathway, Matrix proteins, Mutation, Mutation rate, Neuraminidase, Neuraminidase gene, Nucleic acids, Nucleoprotein, Nucleoprotein gene, Nucleoprotein gene sequence, Nucleotide, Nucleotide sequence analysis, Nucleotide sequences, Nucleotide substitutions, Palese, Pandemic strains, Pathway, Primer, Primer extension, Reassortant viruses, Replication, Separate classes, Sequence Homology, Nucleic Acid, Squirrel monkeys, Subsequent strains, Substitution, Virion, Virology, Virus, Virus strains.

Abstract

Abstract: The nucleotide sequences of RNA segment 5 of an avian influenza A virus, A/Mallard/ NY?6750/78 (H2N2), and a human influenza A virus, A/Udorn/307/72 (H3N2), were determined and the deduced amino acid sequences of the nucleoprotein (NP) of these viruses were compared to two other avian and two other human influenza A NP sequences. The results indicated that there are separate classes of avian and human influenza A NP genes that can be distinguished on the basis of sites containing amino acids specific for avian and human influenza viruses and also by amino acid composition. The human influenza A virus NP genes appear to follow a linear pathway of evolution with the greatest homology (96.9%) between A/NT/60/68 (H3N2) and A/Udorn/72, isolated only 4 years apart, and the least homology (91.1 %)between A/PR/8/34 (H1N1) and A/Udorn/72, isolated 38 years apart. Furthermore, 84% of the nucleotide substitutions between A/PR/8/34 and A/NT/ 6068 are preserved in the NP gene of the A/Udorn/72 strain. In contrast, a distinct linear pathway is not present in the avian influenza NP genes since the homology (90.3%)between the two avian influenza viruses A/Parrot/Ulster/73 (H7N1) and A/Mallard/78 isolated only 5 years apart is not significantly greater than the homology (90.1 %)between strains A/FPV/Rostock/34 and A/Mallard/78 isolated 44 years apart and only 49% of the nucleotide substitutions between A/FPV/34 and A/Parrot/73 are found in A/Mallard/78. A determination of the rate of evolution of the human influenza A virus NP genes suggested that there were a greater number of nucleotide substitutions per year during the first several years immediately following the emergence of anew subtype in 1968.

Url:

https://api.istex.fr/ark:/67375/6H6-PHB0K5C4-B/fulltext.pdf

DOI: 10.1016/0042-6822(86)90198-4

Affiliations:

États-Unis

Links to Exploration step

ISTEX:98084CB03211A541DBD134D38B4116CA43D50FDB

Le document en format XML

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<term>Influenza A virus (genetics)</term>
<term>Nucleoproteins (classification)</term>
<term>Nucleoproteins (genetics)</term>
<term>RNA, Viral (genetics)</term>
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<term>Viral Proteins (genetics)</term>
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<term>Protéines virales (génétique)</term>
<term>Similitude de séquences d'acides nucléiques</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
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<front><div type="abstract" xml:lang="en">Abstract: The nucleotide sequences of RNA segment 5 of an avian influenza A virus, A/Mallard/ NY?6750/78 (H2N2), and a human influenza A virus, A/Udorn/307/72 (H3N2), were determined and the deduced amino acid sequences of the nucleoprotein (NP) of these viruses were compared to two other avian and two other human influenza A NP sequences. The results indicated that there are separate classes of avian and human influenza A NP genes that can be distinguished on the basis of sites containing amino acids specific for avian and human influenza viruses and also by amino acid composition. The human influenza A virus NP genes appear to follow a linear pathway of evolution with the greatest homology (96.9%) between A/NT/60/68 (H3N2) and A/Udorn/72, isolated only 4 years apart, and the least homology (91.1 %)between A/PR/8/34 (H1N1) and A/Udorn/72, isolated 38 years apart. Furthermore, 84% of the nucleotide substitutions between A/PR/8/34 and A/NT/ 6068 are preserved in the NP gene of the A/Udorn/72 strain. In contrast, a distinct linear pathway is not present in the avian influenza NP genes since the homology (90.3%)between the two avian influenza viruses A/Parrot/Ulster/73 (H7N1) and A/Mallard/78 isolated only 5 years apart is not significantly greater than the homology (90.1 %)between strains A/FPV/Rostock/34 and A/Mallard/78 isolated 44 years apart and only 49% of the nucleotide substitutions between A/FPV/34 and A/Parrot/73 are found in A/Mallard/78. A determination of the rate of evolution of the human influenza A virus NP genes suggested that there were a greater number of nucleotide substitutions per year during the first several years immediately following the emergence of anew subtype in 1968.</div>
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Nucleotide sequence analysis of the nucleoprotein gene of an avian and a human influenza virus strain identifies two classes of nucleoproteins

Nucleotide sequence analysis of the nucleoprotein gene of an avian and a human influenza virus strain identifies two classes of nucleoproteins

Source :

Descripteurs français

English descriptors

Abstract

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Links to Exploration step

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